Model ingestion
Upload .xlsx, .xlsm, .csv, or .R files. VIVID parses health states, transition matrices, cost vectors, and utility weights automatically.
.xlsx .csv .R
HTA submissions are under increasing scrutiny
Health technology assessment committees are examining economic models more closely than ever. Assumptions must be transparent, calculations traceable, and results reproducible across jurisdictions. Preparing submissions for agencies such as NICE, CADTH and HIQA now requires a level of validation and transparency that traditional spreadsheet models were never designed to support.
What is VIVID
VIVID is a validation and analysis layer for health economic models. It replaces opaque spreadsheets with a structured pipeline that parses models, verifies assumptions, runs analysis and generates submission-ready outputs across multiple HTA frameworks.
01 — The Problem
HTA evaluation is becoming more forensic.
HTA reviewers now expect full traceability of assumptions, calculations and outcomes. Yet most economic models are still built in spreadsheets that were not designed for transparent validation or cross-jurisdiction analysis.
Black-box models
Excel macros hide critical assumptions. R is difficult to comprehend for non-coders. Reviewers cannot trace calculations from input to output.
Manual validation
Transition probability checks, cohort conservation, discount rate verification — all done by hand, every time.
Framework lock-in
A model built for NICE cannot run against HIQA or CADTH without substantial rework. Multi-country submissions multiply effort.
Irreproducible results
No audit trail. No version control. No way to verify that the PSA used correct distributions or that the DSA varied the right parameters.
02 — Who VIVID is for
Who VIVID is for
VIVID is designed for teams responsible for building and submitting health economic evidence:
- Global HEOR teams preparing HTA submissions
- Market access teams coordinating multi-country evidence packages
- Consultancies building and validating economic models
- Manufacturers preparing submissions to agencies such as NICE, CADTH and HIQA
03 — What's Included?
Everything you need to keep your analysis traceable and audit-ready so you can feel safe submitting models built by humans and AI.
VIVID replaces opaque spreadsheets and R code with a structured analysis pipeline. Upload once, run against any framework, validate automatically.
Framework configuration
Select NICE, HIQA, CADTH, ZIN, or any supported framework. Discount rates, perspective, currency, and WTP thresholds auto-populate from the reference case.
7 reference cases
Sensitivity analysis
1,000-iteration probabilistic sensitivity analysis (PSA). CE plane, CEAC, CEAF. One-way deterministic sensitivity analysis (DSA) with tornado using NMB — never ICER on a dominant result.
PSA + DSA
Automated validation
10 structural checks on every run. Transition probability row sums, cohort conservation, absorbing states, discount rates, half-cycle correction — all verified to 1e-6 tolerance.
10 checks
Submission reporting
NICE-style Table 1, NHB, NMB, disaggregated costs and QALYs, Markov trace. Outputs structured for direct inclusion in HTA submission documents. All assumptions, calculations and outputs are traceable, enabling HTA reviewers and internal teams to understand exactly how results were generated.
NICE Table 1
Multi-jurisdiction
Upload a model once and run it across multiple HTA reference cases. VIVID allows teams to see how results change under NICE, HIQA, CADTH and other frameworks without rebuilding the model for each jurisdiction.
One model, any framework
04 — Process
Upload to validated result in under sixty seconds
A four-step linear pipeline. Every value is editable, every output traces to its inputs.
Upload
Drag and drop a model file or start from a Markov, partitioned survival, or decision tree template.
Configure
Select HTA framework. Review parsed parameters. Edit transitions, costs, utilities inline.
Analyse
Run base-case, PSA, DSA. View Table 1, CE plane, CEAC, Markov trace, tornado, NHB, NMB.
Validate
Over 100 validated checks. Reproducibility verification. Export submission-ready report.
05 — Uncertainty & value
From PSA to submission-ready models
Probabilistic and deterministic sensitivity analyses in one place. CE plane, CEAC, tornado diagrams, and Markov traces are generated from your model and formatted for your target HTA body — so committees see uncertainty and value clearly.
Cost-effectiveness plane
PSA scatter: incremental cost vs incremental QALYs
ΔQALYs (x) · ΔCost (y)
CEAC
Cost-effectiveness acceptability curve by WTP
Markov trace
Cohort proportions by health state over time
Healthy Sick Dead
Tornado diagram
One-way DSA: impact on NMB at threshold
06 — Reference Cases / Frameworks
Pre-configured for every major HTA body
Select a framework. Discount rates, perspective, currency, WTP thresholds, and reporting requirements populate automatically. Parameters are indicative; always confirm against each body’s current reference case.
| Framework | Jurisdiction | Discount rate | Perspective | WTP threshold | Currency |
|---|---|---|---|---|---|
| NICE | England & Wales | 3.5% / 3.5% | NHS & PSS | £20k–£30k | GBP |
| HIQA | Ireland | 4.0% / 4.0% | HSE | €20k–€45k | EUR |
| CADTH | Canada | 1.5% / 1.5% | Public payer | $50k–$100k | CAD |
| ZIN | Netherlands | 4.0% / 1.5% | Societal | €20k–€80k | EUR |
| IQWiG | Germany | 3.0% / 3.0% | SHI | Efficiency frontier | EUR |
| TLV | Sweden | 3.0% / 3.0% | Societal | Severity-adjusted | SEK |